Current Research
Cystic Fibrosis
- Combined Therapy for Infants with Cystic Fibrosis Clinical Trial
- Outcome Measures in Infant/Early Childhood Lung Disease with Chest CT Scanning & Lung Function Testing
Fellowships
CT imaging is exquisitely sensitive to detect regional abnormalities associated with lung disease in children. When correlation between changes in CT findings and lung function parameters were compared in children and adults with cystic fibrosis (CF), CT was found to be more sensitive to early changes in lung disease, often preceding any change in global lung function.
We are interested in studying early regional changes in young and older children with chronic lung disease by utilizing quantitative chest CT post-processing.
We are currently studying regional changes in bronchial wall thickness, a finding consistent with airway inflammation, regional bronchiectasis, a sign of significant progressive airway inflammation and airway remodeling, and regional air trapping, a measure of localized airway obstruction from mucus plugging and/or small airway inflammation in infants, toddlers, and older children with CF and other chronic lung diseases.
