Terry Robinson Lab in the department of Pediatrics
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Pediatric Lung Research

Quantitative Computed Tomography

Cystic Fibrosis Research

Controlled Ventilation Infant CT

Welcome To Terry Robinson's Research Site

My research interests focus on the long term effects of chronic lung disease on respiratory structure and resultant lung function. Current research activities involve measuring structural function with serial CT imaging at similar lung volumes and expiratory CT scans to optimize evaluation of regional small airway disease. The advantage of understanding the molecular and physiologic events of lung disease provides the opportunity for preemptive medical intervention before symptoms appear.

By studying both chest CT scoring and quantitative CT metrics, we are able to study the sensitivity to intervention, thus better understanding the disease process with the goal of translating into practice early diagnosis, prevention and treatment. In previous collaboration with Dr. Michael Goris in the Department of Nuclear Medicine at Stanford University Medical Center, we developed quantitative post-processing methods to determine regional air trapping on chest CT imaging to study small airway disease in children with mild Cystic Fibrosis lung disease.

Current colloaborations include research with Drs. Mark Wiellputz (M.D.) and Oliver Weinheimer (Ph.D.) from the Translational Lung Research Center, Heidelberg University. We are assessing tracheobronchial airway segmentation and analysis, bronchiectasis assessment, and lobar segmentation. We are also collaborating with Dr. Craig Galban (PhD), Director of the Center for Molecular Imaging, University of Michigan, evaluating regional lobar air trapping assessment and analysis of Parametric Response Mapping utilizing co-registered inspiratory and expiratory chest CT scans..

Cystic Fibrosis Lung Disease and Treatment Metrics

To better understand the effect of cystic fibrosis on underlying pulmonary structure, Dr. Robinson has developed spirometer-controlled CT scanning techniques in children and adults with cystic fibrosis. To address the effects of airway remodeling in CF lung disease, quantitative CT post-processing techniques have been developed to allow the measurement of bronchial airways out to the 6th generation.

Recently developed are quantitative methods to match bronchial airways from 2D and 3D CT datasets and currently the lab research is working on quantitative methods to assess bronchiectasis by a bronchial taper index and the quantification of airway mucus plugging.


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